Our purpose is to develop intranasal formulations which can efficiently deliver drugs to the brain/central nervous system (CNS) where drug entry is often restricted by the blood-brain barrier (BBB). To achieve this goal, we must overcome two important challenges; first is an understanding of the direct drug transport mechanism from the nose to the brain, called the "Nose-to-Brain (N2B) route", and second is developing innovative technologies that combines nasal retention and nasal mucosal permeability. We aim to dissolve these problems and develop an ideal nasal applicative formulation for treating brain/CNS diseases with a maximum effect with minimal side effects.