“Structure determines Function, Structure follows Function”
Research and Education in this laboratory are based on this Structure/Function relationship.

The purpose of our research is to reveal the essential mechanisms of untreatable diseases for the development of its novel drugs. Now we are focusing on the two age-related untreatable diseases, dementia and respiratory diseases.

Microtubule-associated protein tau is aggregated and deposited in affected neurons in the brains of dementia including Alzheimer's disease. Such pathological tau is considered to be a cause of functional loss of the neurons. However, the mechanisms of pathogenesis of tau related dementia is largely unknown. Our research goal is to clarify what the essential trigger for physiological tau to acquire such abnormalities is.

Chronic airway disorder is a fatal disease. ACO, a complexed symptom of asthma and COPD, is an increasing syndrome in elderly, but there are no effective drugs. Recently, we originally developed novel animal model of ACO that well mimicking its characteristic symptoms. Using this disease model, we are trying to elucidate the mechanism of airway damage and develop a therapeutic way that inhibit progression of ACO.

Our laboratory is widely accepting undergraduate students, graduate students, and collaborator to research together now. Please feel free to contact us if you are interested in our research projects.